Which of the following statements is NOT true regarding gastrin secretion and function?
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Correct Answer: A. increased production of HCl by parietal cells acts stimulatory on gastrin secretion
Gastrin stimulates parietal cells to release HCl. If A were true, then there would be a positive feedback loop where gastrin is stimulating more HCl production, and HCl is stimulating more gastrin production, causing us to burn a hole through our stomach! Increased production of HCl by parietal cells leads to somatostatin secretion, which inhibits the secretion of gastrin. Lastly, an elevated gastric pH (i.e. low amount of acid) would stimulate the G cells to release more gastrin in an attempt to stimulate the parietal cells to release more HCl to bring the acidity back to normal.
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